The recent fifth edition of World Health Organization and International Consensus Classification in 2022 recognized TP53-mutated myelodysplastic neoplasms (MDS) as a distinct entity requiring multi-hi
供者淋巴细胞输注（DLI）是应对异基因造血干细胞移植（allo-HCT）后复发的重要策略。本研究回顾分析了2010至2022年间，83名在移植后复发并接受DLI的急性白血病或骨髓增生异常综合征（MDS）成年患者。通过每月检测嵌合度和基因标志物，将治疗分为“抢先治疗”（在分子复发时进行）和“常规治疗”（在明显的血液学复发时进行）。 生存分析表明，常规治疗组的生存率显著劣于抢先治疗组，其中常规治疗组
Parkinson's disease (PD) leads to progressive motor and non-motor deficits that compromise activities of daily living (ADL) and quality of life (QoL). Although bilateral deep brain stimulation (DBS) o
Recent advances in digital pathology and artificial intelligence (AI) are transforming our ability to diagnose myeloid neoplasms, including acute myeloid leukemia (AML), myelodysplastic syndromes (MDS
Chronic pain affects approximately 20% of adults worldwide and is a leading cause of disability. Emerging evidence suggest that nutrition may influence pain perception. However, the association betwee
既往研究提示阳光在精神疾病（MD）发展中扮演重要角色，但关于个人接受光照如何影响疾病动态发展的个体层面证据仍有限。本研究基于英国生物样本库，对超27万名参与者进行了前瞻性随访。结果发现，光照时间与首次精神疾病、精神多病共存及死亡风险之间存在非线性关联。每天保持约1.5小时的户外光照，上述风险最低。然而，当每天光照超过1.5小时，反而会显著增加从健康状态恶化至死亡或患精神疾病（尤其是抑郁症、痴呆症和