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Functional immune profiling translates T cell dynamics into predictive biomarkers for myeloma immunotherapy.
Bispecific T cell engagers (TCE) targeting BCMA or GPRC5D have improved outcomes in relapsed/refractory multiple myeloma (MM), yet up to 40% of patients are primarily refractory, and predictive biomar
Bispecific T cell engagers (TCE) targeting BCMA or GPRC5D have improved outcomes in relapsed/refractory multiple myeloma (MM), yet up to 40% of patients are primarily refractory, and predictive biomarkers are scarce. To address this unmet clinical need, we developed an image-based, high-content ex vivo assay using patient-derived bone marrow mononuclear cells exposed to teclistamab or talquetamab. Multiplex immunofluorescence enabled single-cell quantification of plasma cell lysis, T cell expans
本文自动抓取自 PubMed，原文链接：Functional immune profiling translates T cell dynamics into predictive biomarkers for myeloma immunotherapy.
原文发布日期：2026-07-16
