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Leukemic architecture as a framework for risk stratification in NPM1-mutated acute myeloid leukemia.
NPM1-mutated (NPM1c) acute myeloid leukemia (AML) has traditionally been considered a genetically defined entity associated with a favorable prognosis. However, growing evidence indicates that NPM1c A
NPM1-mutated (NPM1c) acute myeloid leukemia (AML) has traditionally been considered a genetically defined entity associated with a favorable prognosis. However, growing evidence indicates that NPM1c AML comprises biologically and clinically heterogeneous disease states, in which NPM1c acts less as an autonomous prognostic determinant and more as a context-dependent organizer of leukemic architecture. Integrative transcriptomic and epigenomic studies have identified reproducible stemness-linked p
本文自动抓取自 PubMed，原文链接：Leukemic architecture as a framework for risk stratification in NPM1-mutated acute myeloid leukemia.
原文发布日期：2026-07-08
